Exercise and Cardiovascular Research Laboratory methods

The goal of the Exercise and Cardiovascular Research Laboratory is to assess the effects of stress, via exercise, the cold pressor test, or the head-up tilt table test, on the cardiovascular system.  To accomplish this task we use multiple methods to better understand the effects of exercise on central and peripheral artery mechanics as well as neural control of the cardiovasculature.  Examination of these variables in healthy individuals is still a growing field.  The more we know about these effects, the more we can properly tailor the exercise regime.  In those with chronic diseases (hypertension, fibromyalgia, diabetes) it can yield valuable insight into how we can use exercise to treat the diseases and better manage the symptoms.

   

Heart Rate Variability: The Biopac allows for measurement of Heart Rate Variability (HRV).  HRV is best defined as the variability in the fluctuations of the R-to-R interval of a tachogram.  From these fluctuations, modulation of the autonomic nervous system can be obtained.  Decreased HRV is strongly associated with the development of cardiovascular disease and cardiovascular events.
 Flow Mediated Dilation

Flow Mediated Dilation:   The GE Logic E ultrasound allows us to quantify arterial diameter and flow mediated dilation (FMD).  Measurement of the artery before and after reactive hyperemia allows us to assess the elasticity of an artery.  FMD is strongly correlated with cardiovascular disease risk and events. 

 

Pulse Wave Analysis:  The SphygmoCor system allows us to measure the time of a reflected pressure wave via pulse wave analysis (PWA).  This transit time and augmented pressure of the reflected wave are strongly correlated with cardiovascular disease, aging and cardiovascular events.

  Pulse Wave Analysis  
  Carotid  

Pulse Wave Velocity: The SphygmoCor system allows us to quantify pulse wave velocity (PWV), or arterial stiffness, both centrally (aorta) and peripherally. We measure pressure waveforms and then correlate them with the electrocardiograph. PWV is strongly linked with cardiovascular disease and all-cause mortality.