Carla J. Aldrich, Ph.D.
Associate Professor of
Microbiology & Immunology
Phone : (812) 465-7168
E-mail : aldrich@iupui.edu
Required text books:
The Immune System, by
Peter Parham. 2nd ed. Garland Publishing, 2005. ISBN: 0 8153
4093-1
Case studies in Immunology,
5th ed., Rosen and Geha. Garland Publishing, 2004. ISBN: 978-2-8153-4145-1
Week
Date
Time
Chapter
Title
Lecturer
1 Monday Jan 7
8:30-10 1
Introduction Aldrich
Wednesday Jan 9 9-10 2 Structure of
Immunoglobulins Aldrich-polycom (p)
Thursday Jan 11 1-2 2 Ig
Genetics Aldrich
Thursday Jan 11 2-3 3 T cell receptor,
MHC molecules Aldrich
Thursday Jan 11 3-4 3 MHC molecules, T
cell ligands Aldrich
2
Monday Jan 14 9-10 3 MHC genetics, Case
studies Aldrich-p
Case studies:
1, congenital asplenia; 12, AID deficiency; 16, Omenn Syndrome
Wednesday Jan 16 9-10 4 B cell development
Aldrich-p
Thursday Jan 17 1-2 5 T cell
development Aldrich
Thursday Jan 17 2-3 6 Trafficking
integrins co-stim APC Aldrich
Thursday Jan 17 3-4 Case
studies Aldrich
Case studies:
17, MHC class I deficiency; 18, MHC class II deficiency; 10, X-linked
agammaglobulinemia; 19 multiple myeloma; 3, leukocyte adhesion deficiency
3
Monday Jan 21 9-10
6 Cytokines Aldrich-p
Wednesday Jan 23 9-10 6 Effector T cells,
B,T cell signaling Aldrich-p
Thursday Jan 24 1-2 7 B cell
immunity Aldrich
Thursday Jan 24 2-3 7-8
Complement Aldrich
Thursday Jan 24 3-4 Case
studies Aldrich
Case studies:
30, Lepromatous leprosy; 24, Autoimmune lymphoproliferative syndrome
(ALPS); 11, Hyper IgM immunodeficiency, 43, Systemic Lupus Erythematosis;
6 Deficiency of the C8 complement component; 4, Hereditary Angioneurotic
Edema; 5, Factor I deficiency
4 Mid Term Exam; 50 questions
Monday, January 28, 2008 AM
Wednesday Jan 30 9-10 houts uses
abs/lys Aldrich-p
Thursday Jan 31 1-2 8 Host defense /
innate Aldrich
Thursday Jan 31 2-3 8 Host
defense/adaptive/mediators Aldrich
Thursday Jan 31 3-4 Case
studies Aldrich
Case studies:
9, x-linked hypohydrotic ectodermal dysplasia and immunodeficiency; 26,
Toxic shock syndrome; 2, chronic granulomatous disease; 45, hemolytic
disease of the newborn; Review case 3, Leukocyte adhesion deficiency; 8,
IL1 receptor-associated kinase 4 deficiency (effects, not details of
pathways); 7, hereditary periodic fever syndrome (just read introduction)
5
*Monday Feb 4
*8-10 9 Immune deficiencies / AIDS
McLaughlin
Handouts-team based session 1
Wednesday Feb 6 9-10 9 Memory,
pathogen evasion
Aldrich-p
Thursday Feb 7 1-2 Case
studies Aldrich
Thursday Feb 7 2-3 Case
studies Aldrich
3-4 team
based session 2 Aldrich
Case studies:
27, acute infectious mononucleosis; 21, interferon-g
receptor deficiency; 14, X-linked severe combined immunodeficiency; 22,
Wiskott-Aldrich Syndrome; 15, Adenosine deaminase deficiency; 23, X-linked
lymphoproliferative syndrome; 31, Acquired Immune deficiency syndrome
(AIDS);
Review cases:
10, X-linked agammaglobulinemia; 11, hyper IgM immunodeficiency; 12,
AID deficiency
6
Monday Feb 11 *8-10
10 allergy/hypersensitivities Jordan-Wagner
Wednesday Feb 13 9-10
Case studies Aldrich-p
Case studies:
32, acute systemic anaphylaxis; 33, allergic asthma; 34 atopic dermatitis;
35 drug induced serum sickness; 37, contact sensitivity to poison ivy
Thursday Feb 14 1-2 11 Autoimmunity &
tolerance Aldrich
Thursday Feb 14 2-3 11 Autoimmunity &
tolerance Aldrich
Thursday Feb 14 3-4 12 Cancer
immunology Aldrich
7
Wednesday Feb20 9-10 Case
studies Aldrich-p
Case studies:
39, autoimmune hemolytic anemia; 46, a kidney graft for complications of
autoimmune insulin dependent diabetes mellitus; 42, rheumatoid arthritis;
44, multiple sclerosis; 40, myasthenia gravis; 38, autoimmune
polyglandular syndrome; 29 rheumatic fever; 41, Pemphigus vulgaris; 36
Celiac Disease; 25 IPEX
Review case:
43, systemic lupus erythematosus
Thursday Feb 21 1-2 12 Transplantation/MHC
Aldrich
Thursday Feb 21 2-3 12 GVHD/Manipulation/vaccines
Aldrich
Thursday Feb 21 3-4 Case
studies Aldrich
Case studies:
47, graft vs. host disease; 28, mixed essential cryoglobluinemia
Review cases
39, T cell lymphoma; 38 multiple myeloma
8 Monday Feb 25
PM 2nd term exam, 50 questions
Thursday Feb 28
1-3 Statewide Final Exam, 60 questions
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