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Redox
Homeostasis
Reactive oxygen
species (ROS) are oxygen species, including both radicals
and non-radicals, that are normally produced in the human
body as a product of metabolism or by inflammatory
phagocytes during immune reactions. ROS can damage
biological molecules and hence have a reputation for harming
cells and causing disease. Recent
development show a second side of ROS. They are important
cell signaling molecules and are required for normal
development and cell functioning.
We are particularly
interested in hydrogen peroxide (H2O2)
signaling. We have shown that under specific metabolically
favorable conditions T cells produce H2O2
at their cell
membrane and that this H2O2
then changes the local redox environment and initiates T
cell receptor signaling. This signaling can result in
promotion of T cell proliferation or death, dependent on the
immunological challenge and T cell's best course of action.
Since T cells
are major regulators in the immune system, improved
knowledge about T cell redox signaling will help us better
understand the aberrant body reactions associated with
excessive immune reactions including inflammation. It will
be a powerful tool for development of novel
anti-inflammatory treatments and of diagnostic tests for
immune diseases.
Biophysical Cell
Regulation
We are further
interested on how to biophysically regulate the cell's redox
potential. We found that narrowband ultraviolet B light and
certain low intensity electromagnetic fields
between 15 and
1000 Hertz can enhance T cell redox signaling leading to T
cell apoptosis. We are currently investigating if ROS metabolism
is included in the primary biological mechanism on how T
cells sense and respond to low energy fields and light. The
data will be used for photodynamic therapy in which cells
are directed down a specific signaling pathway.
Dynamic
Posturography
In a collaboration with Dr. Roy Geib
and others, the use of Computerized Dynamic Posturography is
tested as a method of measuring acquisition of Tai Chi Skill
Levels. For the research, the CAPSTM Professional
system from
Vestibular Technologies Inc.
is used.
Graduate Students:
Hongtao Li, PhD
Sreejith Ramakrishnan,
PhD
Alumni (advisor and committee member):
Aparna Jasti, MS
(Indiana State University)
Brittany Conchi
(Wetzel), PhD (Indiana State University)
Chaitanya Sathe, MS
(Rose-Hulman Institute of Technology)
Cheryl McCreary, PhD
(University of Western Ontario, Canada)
David Chen, MS
(Rose-Hulman Institute of Technology)
Gail Ramirez-Icaza,
PhD (Indiana State University)
Harish Sharma, MS
(Rose-Hulman Institute of Technology)
Heather Aloor, MS.
(Indiana State University)
Lavakumar Karyampudi, PhD
(Indiana State University)
Lisa Hoffhaus, MD
(Indiana University School of Medicine)
Nathan Peterson, MD
(Indiana University School of Medicine)
So-Yon Lim, PhD
(Indiana State University)
Graduate students that work in Dr. Waite's
laboratory receive their stipends and tuition waivers
from Indiana University School of Medicine-Terre Haute.
However, students receive their degrees (M.S. or Ph.D.)
through the host campus (Guidelines
for admission to Indiana State University) or
through an associated university (Guidelines
for admission to Rose-Hulman Institute of Technology).
Undergraduate Students:
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Indiana State
University (LS 492 and LS 192):
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Rose-Hulman
Institute of Technology (BE 390, AB 340)
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J. Johnson
India. Jackson
Gwen Trotter
Joni Goodman
Angie Fulton
Nagadeep
A. Owegi
P. Powell
Adrienne
Metternich
Lori Wheeler
Carie Marusek
Angie Dortch
Paul Haste
Kyle Speakman |
B. Adam
Dan Huey
Krista Gonnerman
S. Smith
Geoff Shrake
C. Cvetan
L. Krause
T. Martin
Derek Trobaugh
Barry Fricke
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Vincennes
University (LS 298):
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University of Notre
Dame:
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E. Gole
A. Rusch
A. Schultz |
Chris Moulton |
In Dr. Waite's laboratory, undergraduate and graduate
students are educated with high success. The following are
selected student awards and presentations at local,
national, and international meetings:
Bioelectromagnetics Society
(BEMS)
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Ms. Brittany Wetzel, EMF
Therapeutics Award for Best Student Presentation on
Clinical Application of EMFs, Travel Award to Quebec,
Canada., 2002
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Ms. Heather Aloor, Curtis
Carl Johnson Memorial Award as well as a Travel Award to
attend the BEMS meeting in St. Paul, MN., 2001
Rocky
Mountain Bioengineering Symposium
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Mr. David Chen, RHIT Travel Award to
Denver, CO, 2007
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Mr. Derek Trobaugh, RHIT, 2nd place
Graduate Research Award, 2006
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Mr. Chaitanya Sathe, RHIT Travel Award
to Rocky Mountain, President's Choice Award, 2005
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Mr. Harish Sharma, RHIT
Travel Award to Biloxi, MS, 2nd place presentation
Award, 2003
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Mr. Ryan Harris, RHIT
Travel Award to Biloxi, MS, 2003
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Ms. Brittany Wetzel,
President’s Choice Award, 2002
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Ms. Aparna Jasti,
President’s Choice Award, 2001
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Ms. Brittany Wetzel, 2nd
place Graduate Research Award, 2001
Research Showcase Indiana State University
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Ms. Angelica Dortch,
Undergraduate Research Award, 2003
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Ms. Lisa Hoffhaus, 2002
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Ms. Heather Aloor,
Graduate Research Award, 2002
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Ms. Hongtao Li, Graduate
Research Award, 2002
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Ms. So-Yon Lim, Graduate
Research Award, 2002
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Ms. Aparna Jasti,
Graduate Research Award, 2001
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Ms. Brittany Wetzel,
Graduate Research Award, 2000
Sigma
Xi Research Competition
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Ms. Angelica Dortch, 2003
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Ms. Heather Aloor, 1st
place Graduate Research, 2001
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Ms. Aparna Jasti, 2001
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Ms. Brittany Wetzel, 1st
place Graduate Research, 2000
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Mr. Philipp Powell, 2nd
place Pre-College Research, 2000
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Ms. Joni Goodman, 1st &
2nd place Undergraduate Research, 1998, 1999
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Ms. Gwen Trotter, 1998
Butler University
Undergraduate Research Forum
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Ms. A. Schultz, 2003
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Ms. A. Rusch, 2002,
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Ms. E. Gole, 2002
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