Professor

Ph.D., University of Calcutta

Phone: 812-237-2416

E-mail: Swapan.Ghosh@indstate.edu

Office: Science Building 287G

Undergraduate and graduate courses taught: Immunology and Lab (BIOL 408/508, 408L/508L), cell Biology (Biol417/517), General biology (Biol112)

Research Interests: tumor immunology, carcinogenesis, immunoregulation and development of sensitive immunoassays for medical application.

Immunology is a rapidly expanding field that advances knowledge of the body's defenses against diseases. Dr. Ghosh's program includes both basic and applied aspects of the subject. The common denominator of these studies is delineation of the cellular and molecular events that occur in the cells of the immune system under normal and pathogenic conditions. Current projects include research in immune regulation of growth and differentiation of lymphoid and mammary tumors with the objectives of:

• Desiging of vaccines to study the effects on tumor microenvironment
• Designing of novel vaccines adjuvants to influence tumor microenvironment
• Effects of modified self-proteins and/ or adjuvants in induction of anti-tumor immunity
• Design of vaccines to prevent or deter bacterial infections
• Biomarkers to assess mobilization of antigen-presenting cells during tumor growth
• developing monoclonal antibodies and immunoassays

SELECTED PATENT & PUBLICATIONS

A US patent on “Phytol derived immunoadjuvants and their use in vaccine formulations” , US Patent # 8,088,395 issued January 3, 2012.

A US patent on “Protein markers associated with bone marrow stem cell differentiation into early progenitor dendritic cells’, US patent # 8334368 issued December 18, 2012.

A Us patent on “Protein biomarkers associated with bone marrow stem cell differentiation into early progenitor dendritic cells # 7,642,045 issued on January 5, 2010

Ghosh Swapan K. & Roshni Roy Chowdhury, Synthetic adjuvants for vaccine formulations: phytol derivatives, Expert opinion on Drug Delivery, DOI. 10.1517/17425247.2013.75591, Informa Healthcare, UK, pp. 1-14, 2013.

Roshni Roy Chowdhury, Richard Fitch & Swapan K. Ghosh, Efficacy of phytol-derived diterpenoid immunoadjuvants over alum in shaping the murine host’s immune response to Staphylococcus aureus, Vaccine, 31: 1178-1186, 2013.

Roshni Roy Chowdhury, Youssef Aachoui, & Swapan K. Ghosh, Effects of small intestinal submucosa (SIS) on the murine innate immune   microenvironment induced by heat-killed Staphylococcus aureus, PLoS ONE 7(11): e48724. doi:10.1371/journal.pone.0048724, pp 1-10, 2012.

Roshni Roy Choudhury and Swapan K. Ghosh, Phytol-derived novel isoprenoid immunostimulants, Frontiers in immunology, doi: 10.3389/fimmu.2012.00049, 2012.

Aachoui  Youssef. and Ghosh Swapan  K. Immune enhancement by novel vaccine adjuvants in autoimmune-prone NZB/W F1 mice:relative efficacy and safety, BMC Immunology , 12:61, 2011.

Aachoui Youssef and Swapan K. Ghosh, Extracellular Matrix from Porcine Small Intestinal Submucosa (SIS) as Immune Adjuvants, PLoS One. 6(11): e27083, 2011.

Aachoui  Youssef.  Roy Chowdhury Roshni , Fitch Richard. W. and Ghosh Swapan. K. Molecular signatures of phytol-derived immunostimulants in the context of chemokine-cytokine microenvironment and enhanced immune response. Cellular Immunology, Volume 271, Issue 2, Pages 227-238, 2011.

Aachoui Y, Schulte ML, Fitch RW, Ghosh SK. Synthetic adjuvants for vaccine formulations: evaluation of new phytol derivatives in induction and persistence of specific immune response. Cell Immunol. , 271(2):308-18. Epub, 2011.

Hongtao Li & Swapan K. Ghosh, CpG ODN 1826 Enhances the Efficacy of Idiotype DNA Vaccine Administered Intrasplenically, The Open Vaccine Journal, pp.127-133 (7), 2010 ( doi: 10.2174/1875035401003010127)

Al-Shaibi Nisreen and Ghosh .S.. K., A novel cell-surface protein CSP82 on bone marrow stem cells and a cytosolic phosphoprotein DP58 (ankyrinRD 34B) are involved in promyeloid progenitor induction, Cell. Immunology, 258, 172-180, 2009 

Al-Shaibi Nisreen, Jonas J. C., and Ghosh .S.K., A bone-marrow cell surface protein CSP82 in generation of dendritic progenitors, Proceedings of 13th International Congress of Immunology, 493-495, 2007

Al-Shaibi, N. King M., Duong T. and Ghosh .S.K., DP58, an inducible myeloid protein is constitutively expressed in murine neuronal nuclei, Frontiers in Bioscience, 12:2947-2956, 2007

Al-Shaib, N.I and Ghosh, S.K. . 2004. A novel phosphoprotein is induced during bone marrow commitment to dentritic cells. BBRC 321(2004):26-30. (Download PDF - 573 kB)

Lim, S.Y. and Ghosh, S.K. 2004. Autoreactive responses to an environmental factor. 2. Phthalate-induced anti-DNA specificity is downregulated by autoreactive cytotoxic T cells. Immunology 112:94-104. (Download PDF - 573 kB)

Sinha, K., Dannelly, H.K., and Ghosh, S.K. 2001. Effects of T-lymphocyte-dependent and -independent immunity on cholinergic enzyme activity in mouse lacrimal gland. Experimental Physiology 86(2):169-176 (Download PDF - 448 kB)

Dannelly, H.K., Liu, Y. & Ghosh, S.K. 2001. Pseudomonas aeruginosa corneal infection affects cholinergic enzymes in rat lacrimal gland. Arch Microbiol 177:47-53. (Download PDF - 178 kB)

Lim, S.Y., Laxmananan, S., Stuart, G.S., and Ghosh, S.K. 2001. Anti-lymphoma immunity: relative efficacy of peptide and recombinant DNA vaccine. Cancer Detection and Prevention 25(5):470-478. (Download PDF - 268 kB)

Laxmanan, S., Stuart, G.W., and Ghosh, S.K. 2001. A stable single-chain variable fragment expressing transfectoma demonstrates induction of idiotype-specific cytotoxic T-cells during early growth stages of a murine B-lymphoma. Cancer Immunol Immunother 50:437-444. (Download PDF - 289 kB)

Murff, C. and Ghosh, S.K. 1998. A Simple Experimental Model to Isolate Antigenic Epitopes Recognized by Antibodies. Bioscene 24(1):11-15. (Download PDF - 620 kB)

Santra, S.K., Sood A. K., and Ghosh S. K. 1999. Cytotoxic effector T cells elicited by the killed tumor vaccine differ from the effectors generated during active growth of a murine B-cell lymphoma. Cancer Immunol. Immunotherp. 48: 421-429. (Download PDF - 200 kB)

Ghosh, S. K., S. Laxmannan, R. Ghosh, and S. Santra S. 1998. Vaccination-induced cytotoxic T-cell responses are different from those generated during in vivo progression of a B-cell lymphoma. Proc. Internat. Congr. Immunol. 10: 1493-1496. (Download PDF - 281 kB)

Ghosh, S. K. & Santra, S.K.. 1998. Cytokine-induced activation of anti-tumor cytotoxic T cells. Trends in Immunology 1: 89-95. (Download PDF - 362 kB)

Santra S. and Ghosh S. K. 1997. Interleukin-4 is effective in restoring cytotoxic T call activity that declines during in vivo progression of a murine lymphoma. Cancer Immunol. Immunother. 44: 291-300. (Download PDF - 309 kB)

Ghosh, S. K. and Chakrabarti, D. 1993. Immunoregulation by processed Ig on B-cells. Ind. J. Biochem. Biophys. 30: 414-421. (Download PDF - 205 kB)

Chakrabarti, D. and S. K. Ghosh. 1992. Induction of syngeneic cytotoxic T lymphocytes against a B cell tumor. I. Role of idiotypic immunoglobulin. Cell. Immunology 142: 54-66. (Download PDF - 156 kB)

Mattingly, M, Chakrabarti, D. & Ghosh, S.K. 1992. Promotion of murine B cell differentiation by 2-mercaptoethanol in contrast to glutathione. FASEB Journal 6:3002-3007 (Download PDF - 1.35MB)

Ghosh, S.K., Patnaik, P. & Bankert, R.B. 1987. Expression of μ and λ-1 membrane forms of immunoglobulin segregate in somatic cell hybrids. Molecular Immunology 24(12):1335-1343. (Download PDF - 368 kB)

Ghosh, S.K., Wong J., & Bankert, R.B. 1987. Idiotype-specific T lymphocytes responsible for the selection of somatic variants of a B cell hybrid. Journal of Immunology 138(7):2230-2235. (Download PDF - 156 kB)

Zylstra, S., Chen, F.A., Ghosh, S.K., Repasky, E.A., Rao, U., Takita, H. & Bankert, R.B. 1986. Membrane-associated glycoprotein (gp160) identified on human lung tumors by a monoclonal antibody. Cancer Research 46:6446-6451. (Download PDF - 177 kB)

Ghosh, S.K. & Roholt, O.A. 1984. Presence of a specific immune complex in the cell-free ascites of a spontaneously metastasizing rat mammary adenocarcinoma, TMT-081. Immunological Communications 13(1):63-76. (Download PDF - 222 kB)

Ghosh, S.K., Roholt, O.A. & Kim, U. 1983. Antigenic characteristics of metastasizing and monmetastasizing mammary adenocarcinomata of rat. In: Non-HLA Antigens in Health, Aging, and Malignancy, pages 227-233. Alan R. Liss, Inc., New York, NY. (Download PDF - 64 kB)

Ghosh, S.K., Grossberg, A.L., Kim, U., & Pressman, D. 1978. Identification and purification of an organ specific, tumor membrane associated antigen from a spontaneously metastasizing rat mammary carcinoma. Immunochemistry 15:345-353. (Download PDF - 1258 kB)

Ghosh, S.K. & Koenig, E. 1977. Isolation of mom-myelin plasma membranes unique to white matter. Biochimica et Biophysica Acta 470:104-112 (Download PDF - 212 kB)